The following books were authored by LIMR researchers
Management of Cardiac Arrhythmias
Gan-Xin Yan, MD, PhD; Peter Kowey, MD; and Charles Antzelevitch, PhD, served as coeditors of the significantly expanded third edition of "Management of Cardiac Arrhythmias" (Springer, 2020). The textbook provides an overview of cardiac arrhythmias and their ECG/telemetry manifestations, including the principles of cardiac electrophysiology, current concepts of pharmacology, clinical features, diagnoses, and state-of-the-art treatments. This book is an essential resource for clinicians specializing in cardiac or vascular surgery, cardiac electrophysiology, and cardiac radiology.
Cardiac Arrhythmias, Pacing and Sudden Death (Cardiovascular Medicine)
Peter Kowey, MD, LIMR professor and world-renowned cardiologist at Lankenau Heart Institute in Lankenau Medical Center, co-authored the textbook "Cardiac Arrhythmias, Pacing and Sudden Death" (Springer, 2017), which provides up-to-date, user-friendly and comprehensive guidance on the evaluation, diagnosis, and medical and surgical treatment of cardiac arrhythmias. The book aids every trainee and practicing cardiologist, cardiac electrophysiologist, cardiac surgeon, vascular surgeon, and physician who manages cardiac patients.
Sunil Thomas, PhD, a research assistant professor who specializes in immunology at LIMR, wrote "Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development" (Springer, 2017), the first comprehensive book that covers every genera of the order Rickettsiales, small proteobacteria that are known to cause diseases in humans and animals.
Preserving the Promise: Improving the Culture of Biotech Investment
For anyone who has ever wondered why—with so much focus and funds flowing into the biotechnology arena—there are relatively few extraordinary breakthroughs realized, a book co-authored by LIMR's Scott Dessain, MD, PhD, can shed light on the challenges. In their book "Preserving the Promise: Improving the Culture of Biotech Investment" (Academic Press, 2016), the authors also point the way to strategies that, if adopted, could improve the chances of more life-saving (and affordable) therapies transitioning from the laboratory to the clinic.
J Wave Syndromes: Brugada and Early Repolarization Syndromes
This book, edited by LIMR Professors Charles Antzelevitch and Gan-Xin Yan, delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs should be directed. The book (Springer 2016) covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics.
Vaccine Design - Methods and Protocols: Volume 1: Vaccines for Human Diseases
This text provides a practical step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. "Vaccines for Human Diseases, Vol. 1" (Humana Press, 2016) has an introductory section on how vaccines impacted diseases, the immunological mechanism of vaccines, future challenges for vaccinologists, and current trends in vaccinology. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases, as well as vaccines for drug abuse, allergy, and tumor vaccines, are also described in this volume.
Vaccine Design - Methods and Protocols, Volume 2: Vaccines for Veterinary Diseases
This text provides step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites. "Vaccines for Veterinary Diseases, Vol. 2" (Humana Press, 2016) includes vaccines for farm animals and fishes, vaccine vectors and production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation and intellectual property.
Cancer Immunotherapy: Immune Suppression and Tumor Growth, 2nd Ed.
This book, co-edited by LIMR President and CEO George Prendergast, PhD, highlights emerging new principles of immune suppression that drive cancer, and it offers new ideas about how therapy can be improved by attacking these principles (Academic Press, 2013).
Recent journal publications authored by LIMR's principal investigators
Burashnikov A. Investigational Anti-Atrial Fibrillation Pharmacology and Mechanisms by Which Antiarrhythmics Terminate the Arrhythmia: Where Are We in 2020? J Cardiovasc Pharmacol. 2020 Nov;76(5):492-505.
Mariotti V, Han H, … Gilman P, et al. Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer: A Randomized Clinical Trial. JAMA Oncol. 2020 Nov 5:e205572. doi: 10.1001/jamaoncol.2020.5572.
Callaghan PJ, Ferrick B, Rybakovsky E, Thomas S, Mullin JM. Epithelial barrier function properties of the 16HBE14o- human bronchial epithelial cell culture model. Biosci Rep. 2020 Oct 30;40(10):BSR20201532.
Thomas S. The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter SemiSWEET. Pathogens and Immunity. 2020; Oct. DOI: 10.20411/pai.v5i1.377.
Hasdemir C, Gokcay F, Orman MN, … Antzelevitch C. Recognition and clinical implications of high prevalence of migraine in patients with Brugada syndrome and drug-induced type 1 Brugada pattern. J Cardiovasc Electrophysiol. 2020 Oct 15. doi: 10.1111/jce.14778.
Fane ME, Ecker BL, Kaur A, … Webster MR, et al. sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients. Clin Cancer Res. 2020 Oct 23. doi: 10.1158/1078-0432.CCR-20-0446.
Merlo LMF, DuHadaway JB, Montgomery JD, Peng W, Murray PJ, Prendergast GC, Caton AJ, Muller AJ, Mandik-Nayak L. Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses. Front Immunol 2020 Aug 18;11:1861.
Walsh R, Lahrouchi N, … Barajas-Martinez H, Antzelevitch C, et al. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls. Genet Med 2020 Sep 7. DOI: 10.1038/s41436-020-00946-5.
Callaghan P, Ferrick B, Rybakovsky E, Thomas S, Mullin J. Epithelial Barrier Properties of the 16HBE14o- Human Bronchial Epithelial Cell Culture Model. Biosci Rep 2020 Sep 28;BSR20201532. doi: 10.1042/BSR20201532.
Barajas-Martinez H, Antzelevitch C, et al. Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes. Stem Cells International. doi.org/10.1155/2020/8842398
Weeraratna A, Fane M, Douglass S, … Webster M, et al. Stromal changes in the aged lung induce an emergence from melanoma dormancy. Nature Research. 2020 Sept. doi: 10.21203/rs.3.rs-61165/v1
Gilmour SK, Alexander ET, Mariner K, Donnelly J, Phanstiel O. Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Anti-Tumor Efficacy of PD-1 Blockade. Mol Cancer Ther. 2020 Aug 3:molcanther.1116.2019. doi: 10.1158/1535-7163.MCT-19-1116.
Nagai K, Ideguchi H, Kajikawa T, … Heber-Katz E, et al. An injectable hydrogel-formulated inhibitor of prolyl-4-hydroxylase promotes T regulatory cell recruitment and enhances alveolar bone regeneration during resolution of experimental periodontitis. FASEB J. 2020 Aug 19. doi: 10.1096/fj.202001248R.
Burashnikov A, Barajas-Martinez H, Hu D, Robinson VM, Grunnet M, Antzelevitch C. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020;76(2):164-72.
Merlo L, DuHadaway J, Montgomery J, Peng WD, Prendergast G, Muller A, Mandik-Nayak L. Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses. Front Immunol. 2020. doi.org/10.3389/fimmu.2020.01861.
Merlo LMF, Bowers J, Stefanoni T, Getts R, Mandik-Nayak L. B-Cell-Targeted 3DNA Nanotherapy Against Indoleamine 2,3-Dioxygenase 2 (IDO2) Ameliorates Autoimmune Arthritis in a Preclinical Model. 2020;13.
Schwartz PJ, Ackerman MJ, Antzelevitch C, et al. Inherited cardiac arrhythmias. Nat Rev Dis Primers. 2020 Jul 16;6(1):58.
Dey S, Sutanto-Ward E, Kopp KL, DuHadaway J, Mondal A, Ghaban D, Lecoq I, Zocca MB, Merlo LMF, Mandik-Nayak L, Andersen MH, Pedersen AW, Muller AJ. Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+ and CD4+ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses. J Immunother Cancer. 2020 Jul;8(2):e000605.
Alicea GM, Rebecca VW, Goldman AR … Webster MR, et al. Changes in Aged Fibroblast Lipid Metabolism Induce Age-dependent Melanoma Cell Resistance to Targeted Therapy Via the Fatty Acid Transporter FATP2. Cancer Discov 2020 Jun 4;CD-20-0329.
Thomas S. An engraved surface induces weak adherence and high proliferation of nonadherent cells and microorganisms during culture. Biotechniques. 2020 Jun 12. doi: 10.2144/btn-2020-0022.
Jackson LR 2nd, Kim S, Blanco R, … Kowey PR, et al. Discontinuation rates of warfarin versus direct acting oral anticoagulants in US clinical practice: Results from ORBIT-AF II. Am Heart J. 2020 Apr 28;226:85-93.
Burashnikov A, Barajas-Martinez H, Hu D, Robinson VM, Grunnet M, Antzelevitch C. The SK Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation via Atrial-selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020 May 20. doi: 10.1097/FJC.0000000000000855.
Lahrouchi N, Tadros R, Crotti L, … Antzelevitch C, et al. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome. Circulation. 2020 May 20. doi: 10.1161/CIRCULATIONAHA.120.045956.
Valenzano MC, Rybakovsky E, Newman G, Mercogliano G, Etemad B, Mullin JM, et al. Zinc Gluconate Induces Potentially Cancer Chemopreventive Activity in Barrett's Esophagus: A Phase 1 Pilot Study. Dig Dis Sci. 2020 May 15. doi: 10.1007/s10620-020-06319-x.
Kowey PR, Robinson VM. The Relentless Pursuit of New Drugs to Treat Cardiac Arrhythmias. Circulation. 2020 May 12;141(19):1507-09.
Thind M, Kowey PR. The Role of the Food and Drug Administration in Drug Development: On the Subject of Proarrhythmia Risk. JInnov Card Rhythm Manag. 2020 Jan 15;11(1):3958-67.
Thomas S. The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter semisweet. Preprints. doi: 10.20944/preprints202004.0512.v1.
Steinberg BA, Holmes DN, Pieper K, … Kowey PR, et al. Factors Associated with Large Improvements in Health-Related Quality of Life in Patients with Atrial Fibrillation: Results from ORBIT-AF. Circ Arrhythm Electrophysiol. 2020 Apr 16. doi: 10.1161/CIRCEP.119.007775.
Hu D, Hu D, Liu L, Charles Antzelevitch, Barajas-Martinez H, et al. Identification, clinical manifestation and structural mechanisms of mutations in AMPK associated cardiac glycogen storage disease. EBioMedicine. 2020 Apr 4;54:102723.
Musa H, Marcou CA, Herron TJ, … Antzelevitch C, et al. Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk. Am J Physiol Heart Circ Physiol. 2020 Mar 20. doi: 10.1152/ajpheart.00481.2019.
Gong M, Yuan M, Meng L, … Yan GX, et al. Wenxin Keli Regulates Mitochondrial Oxidative Stress and Homeostasis and Improves Atrial Remodeling in Diabetic Rats. Oxid Med Cell Longev. 2020 Feb 13;2020:2468031.
Tursi SA, Puligedda RD, … Dessain SK, et al. Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli. Nat Commun. 2020 Feb 21;11(1):1007.
Puligedda RD, Kattala CD, Al-Saleem FH, Dessain SK, et al. Human IgA monoclonal antibodies that neutralize poliovirus produced by hybridomas and recombinant expression. Antibodies 2020, 9(1), 5.
Li KHC, Lee S, Yin C, … Yan GX, et al. Brugada syndrome: A comprehensive review of pathophysiological mechanisms and risk stratification strategies. Int J Cardiol Heart Vasc. 2020 Jan 21;26:100468.
Vamos M, Calkins H, Kowey PR, et al. Efficacy and safety of dronedarone in patients with a prior ablation for atrial fibrillation/flutter: Insights from the ATHENA study. Clin Cardiol. 2019 Dec 24.
Reiffel JA, Verma A, Kowey PR, et al. Rhythm monitoring strategies in patients at high risk for atrial fibrillation and stroke: A comparative analysis from the REVEAL AF study. Am Heart J. 2020 Jan;219:128-36.
Pokorney SD, Holmes DN, Shrader P, … Kowey PR, et al. Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation. Am Heart J. 2019 Oct 23;220:145-54.
Webster MR, Fane ME, Alicea GM, et al. Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. Mol Cell. 2019 Dec 11. pii: S1097-2765(19)30838-X.
Kouiavskaia D, Devudu Puligedda R, Dessain SK, Chumakov K. Universal ELISA for quantification of D-antigen in inactivated poliovirus vaccines. J Virol Methods. 2019 Nov 22:113785.
Thomas S, Laury-Kleintop L, Prendergast GC. Reliable detection of indoleamine 2,3 dioxygenase-1 in murine cells and tissues. Methods Enzymol. 2019;629:219-33.
Kowey PR, Robinson VM. The Evolution of the One-Armed Bandit. J Am Coll Cardiol. 2019 Nov 12;74(19):2376-8.
Antzelevitch C. Tpeak-tend interval as a marker of arrhythmic risk in early repolarization syndrome. J Cardiovasc Electrophysiol. 2019 Aug 20. doi: 10.1111/jce.14118.
Verma A, Wachter R, Kowey PR, et al. Changes in Management Following Detection of Previously Unknown Atrial Fibrillation by an Insertable Cardiac Monitor (from the REVEAL AF Study). Am J Cardiol. 2019 Jun 24.
Milman A, Andorin A, Postema PG, … Yan GX, et al. Ethnic Differences in Patients with Brugada Syndrome and Arrhythmic Events: New Insights from SABRUS. Heart Rhythm. 2019 Jul 5.
Pokorney SD, Holmes DN, Thomas L, Fonarow GC, Kowey PR, et al. Association Between Warfarin Control Metrics and Atrial Fibrillation Outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation. JAMA Cardiol. 2019 Jul 3.
Ingram WM, Weston C, Dar Lu W, Hodge C, Poler SM, Nahi F, Larson S. Factors Affecting Electroconvulsive Therapy Ictal Outcomes: Duration and Postictal Suppression. AMIA Jt Summits Transl Sci Proc. 2019 May 6;672-79,
Nof E, Vysochek L, Meisel E, Burashnikov E, Antzelevitch C, Clatot J, et al. Mutations in NaV1.5 Reveal Calcium-Calmodulin Regulation of Sodium Channel. Front Physiol. 2019 Jun 5;10:700.
Thomas S, Hoxha K, Tran A, Prendergast GC. Bin1 antibody lowers the expression of phosphorylated Tau in Alzheimer's disease. J Cell Biochem. 2019 Jun 18.
Alexander ET, Mariner K, Borodyanskaya Y, Minton A, Gilmour SK. Polyamine-Stimulation of Arsenic-Transformed Keratinocytes. Carcinogenesis. 2019 Jun 12.Katsanis SH, Huang E, Young A, Grant V, Warner E, Larson S, Wagner JK. Caring for trafficked and unidentified patients in the EHR shadows: Shining a light by sharing the data. PLOS ONE 2019 14(3):e0213766.
McCourt DD, Parikh K, Brady AL, Wang Y, Kennedy J, Buckley ME, Ali ZA, Shevade AL, Gilman PB, Wallon UM. The quest for reliable prediction of chemotherapy-induced delayed nausea among breast cancer patients. J Unexplored Med Data 2019;4:6.
Argenziano MA, Doss MX, Tabler M, Sachinidis A, Antzelevitch C. Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis. PLoS One. 2019 May 13;14(5):e0216928.
Cheng J, Amin D, Latona J, Heber-Katz E, Messersmith PB. Supramolecular Polymer Hydrogels for Drug-Induced Tissue Regeneration. ACS Nano. 2019 May 28;13(5):5493-5501.
Rybakovsky E, Valenzano MC, DiGuilio KM, … Mullin JM. Improving Transient Transfection Efficiency in a Differentiated, Polar Epithelial Cell Layer. J Biomol Tech. 2019 Apr 19.
Inohara T, Shrader P, Pieper K, Kowey PR, … et al. Treatment of atrial fibrillation with concomitant coronary or peripheral artery disease: Results from the outcomes registry for better informed treatment of atrial fibrillation II. Am Heart J. 2019 Apr 24;213:81-90.
Back SH, Kowey PR. Strategies to Reduce Recurrent Shocks Due to Ventricular Arrhythmias in Patients with an Implanted Cardioverter-Defibrillator. Arrhythm Electrophysiol Rev. 2019 Mar;8(2):99-104.
Holmes DN, Piccini JP, Allen LA, Kowey PR, … et al. Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score. Circ Cardiovasc Qual Outcomes. 2019 May;12(5):e005358.
Rybakovsky E, Buleza NB, Hoxha K, DiGuilio KM, ... Thomas S, Mullin JM. Spontaneous and cytokine-induced hole formation in epithelial cell layers: Implications for barrier function studies with the gingival cell culture, Gie-3B11, and other epithelial models. Trends in Cell & Molecular Biology. 2018 13:99-114.
Michowitz Y, Milman A, Andorin A … Yan GX, et al. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome. J Am Coll Cardiol. 2019 73(14):1756-65.
Perino AC, Shrader P … Kowey PR, et al. Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT-AF Registry. J Am Heart Assoc. 2019 8(9):e011205.
Vemulapalli S, Inohara T, Kim S … Kowey PR, et al. Blood Pressure Control and Cardiovascular Outcomes in Patients With Atrial Fibrillation (From the ORBIT-AF Registry). American Journal of Cardiology 2019 123(10):1628–36.
Manley K, Bravo-Nuevo A, Minton AR, Sedano S, Marcy A, Reichman M, Tobia A, Artlett CM, Gilmour SK, Laury-Kleintop LD, Prendergast GC. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. J Cell Biochem. 2019 Feb 27.
Madhavan M, Holmes DN, Piccini JP, … Kowey PR, et al. Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation. Am Heart J. 2019 Jan 30;211:77-89.
Puligedda RD, Sharma R, Al-Saleem FH, Kouiavskaia D, Velu AB, Kattala CD, Prendergast GC, Lynch DR, Chumakov K, Dessain SK. Capture and display of antibodies secreted by hybridoma cells enables fluorescent on-cell screening. MAbs. 2019 Feb 22:1-13.
Li X, Sacher F, Kusano KF, Barajas-Martinez H, … Antzelevitch C, et al. Pooled Analysis of Risk Stratification of Spontaneous Type 1 Brugada ECG: Focus on the Influence of Gender and EPS. Front Physiol. 2019 Jan 31;9:1951.
Lemos H, Huang L, Prendergast GC, Mellor AL. Immune control by amino acid catabolism during tumorigenesis and therapy. Nat Rev Cancer. 2019 Mar;19(3):162-175. Review.